Crewe, Newcastle and Kidsgrove are amongst 100 areas getting cash from the Government as part of its new Towns Fund.
The Prime Minister announced the £3.6 billion fund earlier this year, to allow areas to improve transport, broadband connectivity, skills and culture.
It include places with a strong industrial and economic heritage, but have not always benefited from economic growth in the same way as more prosperous areas.
Now, communities, businesses and local leaders in Newcastle, Crewe and Kidsgrove will join forces to draw up ambitious plans to transform their town’s economic prospects.
For Newcastle, it comes on top of the town being selected for Future High Streets Fund cash to create proposals for the Ryecroft area - which could then be paid for by the Government.
Borough Council Leader Simon Tagg said: “We have taken every opportunity to make the Government aware of our need for support to breathe new life into our towns.
"We have put the health of our towns at the heart of our strategy for the borough.
"Those messages are clearly getting through and now we are going to look at how we can unlock resources from this new Towns Fund to benefit our borough’s two towns.
“As further details of this potential funding are confirmed we will make sure we get as much of this £3.6 billion pot as we can to support our work in taking Newcastle and Kidsgrove forward.”
The 100 places invited to develop proposals for a new generation of multi-million-pound Town Deals have today (6 September) been announced by Local Government Secretary Rt Hon Robert Jenrick MP.
He said: "Ensuring that prosperity and opportunities are available to everyone in this country, not just those in London or our biggest cities, is at the heart of the mission of this government.
"We want to level-up our great towns, raising living standards and ensuring they can thrive with transformative investment in transport, technology, skills and culture.
"I will now work with local people from the 100 communities announced today to agree proposals to invest up to £25 million in each place. I hope these deals will provide the investment and the impetus for long-term renewal ensuring each town can look to the future with a new optimism."
Minister for the Northern Powerhouse and Local Growth, Rt Hon Jake Berry MP said: "In July, the Prime Minister promised to level up 100 towns across the country, and today we’re delivering that promise.
"The best answers for local people will come from local people, that’s why we have listened to people living in these towns and will support them with a mega £3.6 billion fund to drive jobs and economic growth.
"Five years on from the launch of the Northern Powerhouse, we are reaffirming our commitment to the people of the North so they have the support they need to be at the leading edge of a confident, global Britain when we leave the EU on 31 October."